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OSTbeta

OST-beta together with OST-alpha is able to transport estrone sulfate, taurocholate, digoxin, and prostaglandin E2 across cell membranes. The Ost-alpha / Ost-beta heterodimer, but not the individual subunits, stimulates sodium-independent bile ac ...

                                               

PAK6

Serine/threonine-protein kinase PAK 6 is an enzyme that in humans is encoded by the PAK6 gene. PAK6 belong to group II members of the family PACK. Like other members of the family, PAK6 is also evolutionary conserved in different species.

                                               

PCSK6

Proprotein convertase subtilisin/kexin type 6 is an enzyme that in humans is encoded by the PCSK6 gene. PCSK6 is a protease that cleaves NODAL into an active form to help trigger the development of left/right asymmetry. It may also be involved in ...

                                               

PDCD7

Programmed cell death protein 7 is a protein that in humans is encoded by the PDCD7 gene. This gene encodes a protein with sequence similarity to the protein, initially identified in mouse embryonic stem cells. In Mouse t-cell lines, this protein ...

                                               

PIAS1

This gene encodes a member of the mammalian PIAS family. This member contains a putative zinc-binding motif and a highly acidic region. It inhibits STAT1-mediated gene activation and the DNA binding activity, binds to Gu protein/RNA helicase II/D ...

                                               

PIF1 5-to-3 DNA helicase

This gene encodes a DNA-dependent adenosine triphosphate ATP-metabolizing enzyme that functions as a 5 to 3 DNA helicase. The encoded protein can resolve G-quadruplex structures and RNA-DNA hybrids at the ends of chromosomes. It also prevents tel ...

                                               

PIGB

GPI mannosyltransferase 3 is an enzyme that in humans is encoded by the PIGB gene. This gene encodes a transmembrane protein located in the endoplasmic reticulum and is involved in GPI-anchor biosynthesis. In glycosylphosphatidylinositol GPI anch ...

                                               

PLA2G4E (gene)

This gene encodes a member of the cytosolic phospholipase A2 group IV family. Members of this family are involved in regulation of membrane tubule-mediated transport. The enzyme encoded by this member of the family plays a role in trafficking thr ...

                                               

PLCB2

The gene codes for the enzyme phospholipase C β2. The enzyme catalyzes the formation of inositol 1.4.5-trisphosphate and diacylglycerol from phosphatidylinositol 4.5-bisphosphate. This reaction uses calcium as a cofactor and plays an important ro ...

                                               

PLDN

The protein encoded by this gene may play a role in intracellular vesicle trafficking. It interacts with Syntaxin 13 which mediates intracellular membrane fusion. Several alternatively spliced transcript variants of this gene have been described, ...

                                               

PPIB

Peptidyl-prolyl cis-trans isomerase B is an enzyme that is encoded by the PPIB gene. As a member of the peptidyl-prolyl cis-trans isomerase family, this protein catalyzes the cis-trans isomerization of proline imidic peptide bonds, which allows i ...

                                               

PRC1

PRC1 protein is expressed at relatively high levels during S and G2/M phases of the cell cycle before dropping dramatically after mitotic exit and entrance into G1 phase. PRC1 is located in the nucleus during interphase, becomes associated with t ...

                                               

Promyelocytic leukemia protein

Promyelocytic leukemia protein is the protein product of the PML gene. PML protein is a tumor suppressor protein required for the assembly of a number of nuclear structures, called PML-nuclear bodies, which form amongst the chromatin of the cell ...

                                               

Protein 4.2

Erythrocyte membrane protein band 4.2 is a protein that in humans is encoded by the EPB42 gene. Protein 4.2 is a cytoskeleton protein found in red blood cells. Erythrocyte membrane protein band 4.2 is an ATP-binding protein which may regulate the ...

                                               

PSMA4

Proteasome subunit alpha type-4 also known as macropain subunit C9, proteasome component C9, and 20S proteasome subunit alpha-3 is a protein that in humans is encoded by the PSMA4 gene. This protein is one of the 17 essential subunits that contri ...

                                               

PTPN9

The protein encoded by this gene is a member of the protein tyrosine phosphatase PTP family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogen ...

                                               

RAB11A

The protein encoded by this gene belongs to the small GTPase superfamily, Rab family. It is associated with both constitutive and regulated secretory pathways, and may be involved in protein transport. RAB-11a controls the intracellular trafficki ...

                                               

RAB27A

The protein encoded by this gene belongs to the small GTPase superfamily, Rab family. The protein is membrane-bound and may be involved in protein transport and small GTPase mediated signal transduction. Mutations in this gene are associated with ...

                                               

RASGRF1

Ras protein-specific guanine nucleotide-releasing factor 1 is a protein in humans that is encoded by the RASGRF1 gene. The protein encoded by this gene is a guanine nucleotide exchange factor GEF similar to the Saccharomyces cerevisiae CDC25 gene ...

                                               

Retinaldehyde-binding protein 1

Retinaldehyde-binding protein 1 also known as cellular retinaldehyde-binding protein is a 36-kD water-soluble protein that in humans is encoded by the RLBP1 gene.

                                               

RMDN3

Regulator of microtubule dynamics protein 3, more commonly known as Protein tyrosine phosphatase interacting protein 51, is a protein that in humans is encoded by the RMDN3 gene on chromosome 15. This protein contributes to multiple biological fu ...

                                               

RNF111

The protein encoded by this gene contains a RING finger domain, a motif known to be involved in protein-protein and protein-DNA interactions. The mouse counterpart of this gene Rnf111/arkadia has been shown to genetically interact with the transf ...

                                               

RTF1

Rtf1, Paf1/RNA polymerase II complex component, homolog is a protein that in humans is encoded by the RTF1 gene. This locus may represent a gene involved in the regulation of transcription elongation and chromatin remodeling, based on studies of ...

                                               

SCAMP2

Secretory carrier-associated membrane protein 2 is a protein that in humans is encoded by the SCAMP2 gene. This gene product belongs to the scamp family of proteins which are secretory carrier proteins of the membrane. They function as carriers t ...

                                               

SCG3

The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Granins may serve as precursors for biologically active peptides. Some granins have been shown to function as helper prote ...

                                               

SCG5

Neuroendocrine protein 7B2 is a protein that in humans is encoded by the SCG5 gene. The protein expressed by this gene is widely distributed in neuroendocrine tissues. It functions as a chaperone protein for the proprotein convertase PC2 by block ...

                                               

SENP8

Sentrin-specific protease 8 is an enzyme that in humans is encoded by the SENP8 gene. MIM 603171 NEDD8 is a ubiquitin-like protein that becomes conjugated to Kallio to see CUL1, subunits of MIM 603134 several ubiquitin ligase. This pairing, calle ...

                                               

SNAP23

Synaptosomal-associated protein 23 is a protein that in humans is encoded by the SNAP23 gene. Two alternative transcript variants encoding different protein isoforms have been described for this gene.

                                               

SNX1

Sorting nexin-1 is a protein that in humans is encoded by the SNX1 gene. The protein encoded by this gene is a sorting nexin. SNX1 is a component of the retromer complex.

                                               

Sodium/potassium/calcium exchanger 5

Sodium/potassium/calcium exchanger 5, also known as solute carrier family 24 member 5, is a protein that in humans is encoded by the SLC24A5 gene that has a major influence on natural skin colour variation. The NCKX5 protein is a member of the po ...

                                               

Sorbitol dehydrogenase

Sorbitol dehydrogenase is a cytosolic enzyme. In humans this protein is encoded by the SORD gene. Sorbitol dehydrogenase are enzymes involved in carbohydrate metabolism converting sorbitol, the sugar alcohol form of glucose into fructose. Along w ...

                                               

SPG21

Maspardin is a protein that in humans is encoded by the SPG21 gene. The protein encoded by this gene was identified in two-hybrid screen using CD4 as the bait. It binds to the hydrophobic C-terminal amino acids of CD4 which are involved in the su ...

                                               

SPN1

Snurportin1 is a protein that in humans is encoded by the SNUPN gene. Nuclear import of the spliceosomal snRNPs U1, U2, U4 and U5, is dependent on the availability of a complex nuclear localization signal. The latter consists of 5-2.2.7-trimethyl ...

                                               

SPPL2A

This gene is a member of the signal peptide peptidase-like protease SPPL family and encodes a lysosomal/late endosomal membrane protein with the conserved active site motifs YD and GxGD in adjacent transmembrane domains TMDs. This protein plays a ...

                                               

SPTBN5

Spectrin, beta, non-erythrocytic 5 also known as SPTBN5 is a protein that in humans is encoded by the SPTBN5 gene. SPTBN5 belongs to the spectrin family of cytoskeletal proteins.

                                               

ST8SIA2

The protein encoded by this gene is a type II membrane protein that is thought to catalyze the transfer of sialic acid from CMP-sialic acid to N-linked oligosaccharides and glycoproteins. The encoded protein may be found in the Golgi apparatus an ...

                                               

STARD5

StAR-related lipid transfer protein 5 is a protein that in humans is encoded by the STARD5 gene. The protein is a 213 amino acids long, consisting almost entirely of a StAR-related transfer domain. It is also part of the StarD4 subfamily of START ...

                                               

STRC

Stereocilin is a protein that in humans is encoded by the STRC gene. This gene encodes a protein that is associated with the hair bundle of sensory hair cells in the inner ear. Set of hair consists of stiff microvilli called stereocilia and are i ...

                                               

Synemin

Synemin, also known as desmuslin, is a protein that in humans is encoded by the SYNM gene. Synemin is an intermediate filament family member. IF proteins are cytoskeletal proteins that confer resistance to mechanical stress and are encoded by a d ...

                                               

TCF12

Transcription factor 12 is a protein that in humans is encoded by the TCF12 gene. The protein encoded by this gene is a member of the basic helix-loop-helix bHLH e-protein family that recognizes the consensus binding site e-box CANNTG. This encod ...

                                               

Thrombospondin 1

Thrombospondin 1, abbreviated as THBS1, is a protein that in humans is encoded by the THBS1 gene. Thrombospondin-1 is a subdivision of a disulfide-linked homotrimeric protein. This protein is an adhesive glycoprotein that mediates cell-to-cell an ...

                                               

Tight junction protein 1

Zonula occludens-1 ZO-1, also known as Tight junction protein-1 is a 220-kD peripheral membrane protein that is encoded by the TJP1 gene in humans. It belongs to the family of zona occludens proteins, which are tight junction-associated proteins ...

                                               

TLN2

Talin 2 is a protein in humans that is encoded by the TLN2 gene. It belongs to the talin protein family. This gene encodes a protein related to talin 1, a cytoskeletal protein that plays a significant role in the assembly of actin filaments. Tali ...

                                               

TP53BP1

DNA double-strand breaks DSBs are cytotoxic damages that can be repaired either by the homologous recombinational repair HR pathway or by the non-homologous end-joining NHEJ pathway. NHEJ, although faster than HR, is less accurate. The early dive ...

                                               

TPM1

Tropomyosin alpha-1 chain is a protein that in humans is encoded by the TPM1 gene. This gene is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and s ...

                                               

Tropomodulin 2

This gene encodes a neuronal-specific member of the tropomodulin family of actin-regulatory proteins. The encoded protein caps the pointed end of actin filaments preventing both elongation and depolymerization. The capping activity of this protei ...

                                               

TSPAN3

Tetraspanin-3 is a protein that in humans is encoded by the TSPAN3 gene. The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that a ...

                                               

TTBK2

Tau tubulin kinase 2 is a protein in humans that is encoded by the TTBK2 gene. This gene encodes a serine-threonine kinase that putatively phosphorylates tau and tubulin proteins. Mutations in this gene cause spinocerebellar ataxia type 11, a neu ...

                                               

TUBGCP4

Tubulin, gamma complex associated protein 4 is a protein in humans that is encoded by the TUBGCP4 gene. It is part of the gamma tubulin complex, which required for microtubule nucleation at the centrosome.

                                               

TUBGCP5

Gamma-tubulin complex component 5 is a protein that in humans is encoded by the TUBGCP5 gene. It is part of the gamma tubulin complex, which required for microtubule nucleation at the centrosome.